7/30/2023 0 Comments Single cell sequence![]() First, epigenetic regulation stands at the center of the gene regulatory networks, study of which provides important insights into how transcription is regulated and how epigenetic memory is established and maintained in stem cells as well as their differentiated progenies. In this review, we will discuss recent advances in single-cell omics sequencing technologies in four topics. With rapid development of the technology, including tremendous improvement of throughput, accuracy, automation, and commercialization, scRNA-seq techniques have been widely applied to address critical biological and medical questions. This starts from the first single cell RNA-seq (scRNA-seq) technique developed in 2009 1. In recent years, single-cell omics sequencing technologies have been resolving many of these issues and revolutionizing the stem cell field. They are quite often heterogeneous, containing distinct subtypes or distinct biological states, such as quiescent and actively proliferating states, and there are also intermediate cell subpopulations during their multi-lineage differentiation processes. Stem cells are generally rare in organs and are located at specific positions surrounded and controlled by well-organized niche cells. In many organs of an adult individual, stem cells are continuously self-renewing and differentiating to maintain the lifelong physiological functions of the organs. ![]() The huge cellular heterogeneity and complexity represent a major bottleneck and pose great challenges for research on human development, stem cell biology and many other fields. A single cell zygote at the starting point of our life develops into 37 trillion cells in our body.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |